The early annuals may be scarce or tricky to come by but there is really little collector interest.
Things only really get going with the 1963 to 1969 annuals which feature Supercar, Fireball XL5, Doctor Who (Patrick Troughton incarnation) and The Avengers with Diana Rigg's Emma Peel character. These can fetch eye-popping prices in very high grade (but I do mean very high grade). The Tom Baker Doctor Who appearances from 1975-1980 are also worth watching out for.
Note: some PR issues may have no value. Selected issues in FN, VF or VF/NM may not exist in some titles.